TP53

If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, summoning a repair team before allowing the cell to carry on dividing

All of us have lurking in our DNA a most remarkable gene, which has a crucial job – it protects us from cancer. Known simply as p53, this gene constantly scans our cells to ensure that they grow and divide without mishap, as part of the routine maintenance of our bodies. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, summoning a repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control, p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged or prevented from functioning normally. Perhaps unsurprisingly, p53 is the most studied single gene in history. This book tells the story of medical science’s mission to unravel the mysteries of this crucial gene, and to get to the heart of what happens in our cells when they turn cancerous. Through the personal accounts of key researchers, p53: The Gene that Cracked the Cancer Code reveals the fascination of the quest for scientific understanding, as well as the huge excitement of the chase for new cures – the hype, the enthusiasm, the lost opportunities, the blind alleys, and the thrilling breakthroughs. And as the long-anticipated revolution in cancer treatment tailored to each individual patient’s symptoms begins to take off at last, p53 remains at the cutting edge.

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various or

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Happiness by design

Outstanding, cutting-edge, and profound. If you’re going to read one book on happiness, this is the one’ Nassim Nicholas Taleb

How can we make it easier to be happy? Using the latest cutting-edge research, Professor Paul Dolan reveals that wellbeing isn’t about how we think – it’s about what we do. By making deliberate choices that bring us both pleasure and meaning, we can redesign our lives for maximum happiness – without thinking too hard about it.

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Triple package

Why do Jews win so many Nobel Prizes and Pulitzer Prizes?

Why are Mormons running the business and finance sectors? Why do the children of even impoverished and poorly educated Chinese immigrants excel so remarkably at school? It may be taboo to say it, but some cultural groups starkly outperform others. The bestselling husband and wife team Amy Chua, author of Battle Hymn of the Tiger Mother, and Jed Rubenfeld, author of The Interpretation of Murder, reveal the three essential components of success – its hidden spurs, inner dynamics and its potentially damaging costs – showing how, ultimately, when properly understood and harnessed, the Triple Package can put anyone on their chosen path to success.

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Science book

All the big ideas in science, simply explained

Part of the popular Big Ideas series, The Science Book explores the history of science, how scientists have sought to explain our incredible universe and how amazing scientific discoveries have been made. Discover how Galileo worked out his scientific theories of motion and inertia, why Copernicus’s ideas were contentious and what the discovery of DNA meant. All the big scientific ideas and discoveries are brought to life with quirky graphics, pithy quotes and step-by-step ‘mind maps’, plus every area of science is covered, including astronomy, biology, chemistry, geology, maths and physics. You’ll be brought up-to-date on scientific ideas from black holes to genetic engineering with eye-catching artworks showing how the ideas of key scientists have impacted our understanding of the world. Whether you are a science student or just have an interest in scientific ideas, The Science Book is a perfect way to explore this fascinating subject.

A science book is a work of nonfiction, usually written by a scientist, researcher, or professor like Stephen Hawking (A Brief History of Time), or sometimes by a non-scientist such as Bill Bryson (A Short History of Nearly Everything). Usually these books

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The Sports Gene

Inside the Science of Extraordinary Athletic Performance

The Sports Gene is a book written by David Epstein, a senior writer for Sports Illustrated, on the effects of genetics and sports training on human athleticism. Through investigative journalism, Epstein takes the reader through his experiences regarding what makes the difference between an amateur and a pro-athlete. The book was published in August 2013 by Penguin Books.

The Sports Gene is a book written by David Epstein, a senior writer for Sports Illustrated, on the effects of genetics and sports training on human athleticism. Through investigative journalism, Epstein takes the reader through his experiences regarding wh

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Essential project management

Project management procedures and how they should be implemented

An account of project management techniques to fit the needs of the non-specialist. Concentrating on the tasks of project definition, organization, estimating, planning and control and the role of purchasing, the book explains project management procedures and how they should be implemented.

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You can understand your dreams

This essential book teaches you everything you need to know about the dream world

You Can Understand Your Dreams is a practical guide to using our dreams to bring greater fulfilment into our waking lives. Drawing upon traditional Jungian analysis and techniques developed for his dream workshops, the late Professor David Fontana presents a series of nearly 30 exercises designed to improve the quality of dreams by making them more vivid and revealing, opening a path of step-by-step self-discovery and self-enrichment. Fontana’s numerous methods include contacting the dream world via the technique of recall or keeping a dream diary, combining extraordinary insight with practicality. He also suggests effective methods for remembering dreams, interpreting them, and decoding the vital messages they bring from the subconscious. He explains how dreams can help you to deal better with anxieties and enhance your personal relationships, and concludes with an A – Z directory of dream symbols and their meanings.

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Getting things done

GTD’ is now shorthand for an entire way of approaching professional and personal tasks

Since it was first published almost fifteen years ago, David Allen’s Getting Things Done has become one of the most influential business books of its era, and the ultimate book on personal organization. ‘GTD’ is now shorthand for an entire way of approaching professional and personal tasks, and has spawned an entire culture of websites, organizational tools, seminars, and offshoots. Allen has rewritten the book from start to finish, tweaking his classic text with important perspectives on the new workplace, and adding material that will make the book fresh and relevant for years to come. This new edition of Getting Things Done will be welcomed not only by its hundreds of thousands of existing fans but also by a whole new generation eager to adopt its proven principles.

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Timeline of history

Timelines of History makes the past accessible to all families, students, and the general reader.

Timelines of History takes readers through the history of cultures and nations around the world from the emergence of our earliest African ancestors to the present day. Dynamic timeline spreads, features on influential people, places, events and innovations, and easily accessible cross-references all build into a narrative that takes readers back and forth through time.

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Sapiens: A Brief History of Humankind

This is the thrilling account of our extraordinary history – from insignificant apes to rulers of the world.

FIRE gave us power. FARMING made us hungry for more. MONEY gave us purpose. SCIENCE made us deadly. This is the thrilling account of our extraordinary history – from insignificant apes to rulers of the world.

Sapiens: A Brief History of Humankind (Hebrew: קיצור תולדות האנושות‎‎) is a book by Professor Yuval Noah Harari first published in Hebrew in Israel in 2011, and in English in 2014. Harari cites Jared Diamond’s Guns, Germs, and Steel (1997) as one of the gr

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Science for life

Science for Life is your guide to surviving and thriving in the modern world

In Science for Life acclaimed science writer Brian Clegg cuts through the vested interests and confusing contradictory statements that litter the media and the internet, to give a clear picture of what science is telling us right now about changing our lives for the better. Discover the much-advertised antioxidants that aren’t good for you, the truth about fat and sugar and why one of the healthiest foods contains carcinogens and 21 E-numbers. Find out what does and what doesn’t enhance brainpower – from the failure of playing Mozart to babies to the surprising abilities of caffeine and nicotine. Understand the tools that advertisers use to persuade us and how to turn the psychological pressure back on them. From the shortcomings of the five second rule to the truth about phone masts and nuclear power, kept up-to-date on a partnering website, Science for Life is your guide to surviving and thriving in the modern world.

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Physical exercise

Workouts for shredding abs, sculpting massive biceps, pecs, delts, glutes and more!

The Men’s Health Little Book of Exercises is a handy instruction manual to more than 250 of the best exercises and workouts for torching fat and losing weight, shredding abs, and sculpting massive biceps, pecs, delts, glutes and more! With detailed step-by-step photos, the book will instruct you how to execute each move with perfect form to challenge every muscle fibre for better, faster results. Special advice includes ‘how to add 50 pounds to your bench press’, ’10 ways to add inches to your arms’, ‘the best abs exercises you’re not doing but should’ and ‘4 surprising foods that burn fat and build muscle’.

Physical exercise is any bodily activity that enhances or maintains physical fitness and overall health and wellness. It is performed for various reasons, including increasing growth and development, preventing aging, strengthening muscles and the cardiova

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Richard Templar

Pithy, self-contained ideas are so straightforward that you can even read the book itself without trying too hard

In this clever book, bestselling author Richard Templar delivers a collection of principles, tactics and techniques that will make sure things always get done, without you ever having to break a sweat or stay up into the small hours to do it.

Richard Templar is the pen name of a British author who has written several self-development books. He shares his “path to success” in a series of books, in which 100 simple “Rules” are presented to achieve success: be it in business, money, or life in gen

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Loire valley

Visit the magnificent Château de Chambord

The ideal travel companion, full of insider advice on what to see and do, plus detailed itineraries and comprehensive maps for exploring this tranquil and picturesque region. Visit the magnificent Château de Chambord, take a wine and cheese tour around Sancerre, enjoy the lively atmosphere of medieval Tours or be amazed at the giant mechanical creatures at Les Machines de l’Ile in Nantes: everything you need to know is clearly laid out within colour-coded chapters. Discover the best of the Loire Valley with this indispensable travel guide.

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Facebook youtube myspace

The people, the hype and the deals behind the giants of WEB 2.0

After the dot com crash, many people thought it was the end of the internet era. They were mistaken, as a new wave of internet initiatives have begun, focused on blogging, social networking and file sharing, and dubbed Web 2.0. Many of us are familiar with the sites of Facebook, YouTube, MySpace, but how did these phenomenons begin? And why are they so popular? This book explores the stories behind these sites, quashing the rumours and explaining how these internet giants began. It also uncovers the start-up stories behind Digg, Six Apart, Slide, Founders Fund, Yelp, LinkedIn, Twitter, Ning, and Revision3. These compelling accounts are put together through interviews with the founders of these companies. Author, Sarah Lacy has reported on start-ups and venture capital for Business Week in Silicon Valley for nearly a decade and was one of the only journalists who stayed around after the dot com crash.

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Fast projects

Project Management When Time is Short

We are all faced with projects going off the rails, veering far from what we initially set out to do, costing ten times as much and taking far too long to complete – this is just part of everyday working life. Honing our general skills in project management seems like the obvious answer, but Fast Projects promises a quicker and easier solution – cutting the time to get projects done in the first place.Learning to operate within a short schedule not only cuts costs and improves revenue and cash flow, but it also sets you aside as a sharper and slicker operation. How to build, shorten and execute a realistic plan in the shortest time possible is covered in detail along with a specific focus on ensuring you have clearly defined goals and are making accurate project predictions with a successful tracking progress. Using worked examples and tried and tested techniques, Fast Projects is your practical guide to ensuring projects not only succeed, but are delivered early. If you want to get the most out of your team and take control of your workload, resources and time, this book is for you.

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Gigya

Gigya Inc. is a technology company founded in Tel Aviv, Israel and headquartered in Mountain View, California with additional offices in New York, Tel Aviv, London, Paris, Hamburg, and Sydney. Gigya Inc. provides a Customer Identity and Access Management p

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How to make a fortune on the internet

1.Get an idea; 2. Register the name and build the website; 3. Develop products and services list to sell (optional); 4. Get traffic…

If you can point and click a mouse, type on a keyboard and have a basic grasp of the English language then you can make a fortune on the internet if you know what to do. This book will show you exactly what to do. You will learn how to: – Build a website and go live in 1 hour – Accept online payments and set up statements to track your income – Drive traffic to your site by getting your site listed instantly with the major search engines like Yahoo and Google. – Earn up to GBP10 per click every time someone clicks on your site – Earn up to GBP115 every time someone fills out a form on your site – Get other web publishers to sell your stuff – Create a database of readers you can profit from every time you update your site – Have a chat room, forum and video forum on your website for free – Automatically send out an email everyday with no input from you – Incorporate a search box on your site that makes you money every time someone searches – Add ready-made articles about your chosen subject to your site completely free – simply copy and paste!

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Lazy project manager

How to be twice as productive and still leave the office early

Peter Taylor reveals how adopting a more focused approach to life, projects and work can make you twice as productive. The lazy project manager illustrates how anyone can apply the simple techniques of lazy project management in their own activities in order to work more effectively and consequently improve work-life balance. This ‘productive laziness’ approach builds on the Pareto principle that states that for many phenomena, 80 per cent of consequences stem from 20 per cent of the causes. To put it simply, only 20 per cent of the things people do during their working days really matter. Inside this insightful and informative book you’ll discover: * The intelligence of laziness – why smart, lazy people have the edge over others; * Why the Jungle Book’s ‘Bare Necessities’ should be the productive lazy theme tune; * How to get the maximum output for a minimised input; * Quick tips to productive lazy heaven. Everyone wants to achieve more without chaining themselves to their desk. By concentrating your project management and learning to exercise effort where it really matters, you can learn to work smarter. Welcome to the home of ‘productive laziness’.

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Lean startup

How Constant Innovation Creates Radically Successful Businesses

The Lean Startup is a new approach to business that’s being adopted around the world. It is changing the way companies are built and new products are launched. The Lean Startup is about learning what your customers really want. It’s about testing your vision continuously, adapting and adjusting before it’s too late. Now is the time to think Lean.

Lean startup is a methodology for developing businesses and products, which aims to shorten product development cycles by adopting a combination of business-hypothesis-driven experimentation, iterative product releases, and validated learning. The central

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Marketing on beermat

Unlike most marketing books, Marketing on a Beermat is aimed exclusively at small and growing businesses. It is accessible, comprehensive and written by people who have years of experience in the start-up sector. It is guaranteed to give your small business the edge.

Marketing is the driving force of every small business, but many budding entrepreneurs are unsure how best to go about it. Marketing on a Beermat, written by Beermat Entrepreneur Chris West, brilliantly demystifies this essential area of business enterprise, telling you everything you need to know about researching and identifying customers, creating an impressive marketing strategy, building marketing campaigns, and increasing consumer awareness and – therefore – sales. It also shows that you don’t need a huge marketing budget to get results, and reveals the inexpensive but ingenious ‘tricks of the trade’ that are guaranteed to pay dividends. Finally, it provides crucial insights into online resources and the UK media.

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Project managemer master art of delivery

Successful project management is ultimately about effective communication, and more broadly, effective people management. Most books, however, deal largely with process – the mechanical, methodological side, and play down the human side.

The Project Manageris a fresh approach to project management: it moves beyond the formal methodologies and techniques to shed light on the core skills that will make you a great project manager. It puts the project manager centre stage and provides you with an invaluable set of experience-based lessons, tips, and advice to help you consistently deliver the results you want. Whether you are a project manager yourself, or someone who works with or recruits project managers, this book will be essential reading.

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Teach Yourself Project Management

Discover How to build the right team chemistry and how to manage the financial aspects of any project,

you need to run projects to schedule and to budget? Are you lacking confidence to tackle big projects? Do you need to create a solid team? Teach Yourself Project Management is a practical introduction to this essential skill. Written for all readers, it explains and illustrates the what, why, where, when and how of project management in an accessible format. Jargon-free and based on sound theory, with diagrams, useful ideas and pointers to appropriate methods and tools, it’s THE book for anyone who wants to develop the skills of effective project management. New to this edition are useful risk assessment checklists and planning and specification questionnaires to reassure the reader that they are on on track.

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Project management teach yourself

Discover How to build the right team chemistry and how to manage the financial aspects of any project,

you need to run projects to schedule and to budget? Are you lacking confidence to tackle big projects? Do you need to create a solid team? Teach Yourself Project Management is a practical introduction to this essential skill. Written for all readers, it explains and illustrates the what, why, where, when and how of project management in an accessible format. Jargon-free and based on sound theory, with diagrams, useful ideas and pointers to appropriate methods and tools, it’s THE book for anyone who wants to develop the skills of effective project management. New to this edition are useful risk assessment checklists and planning and specification questionnaires to reassure the reader that they are on on track.

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Project manager master of delivery

Successful project management is ultimately about effective communication, and more broadly, effective people management. Most books, however, deal largely with process – the mechanical, methodological side, and play down the human side.

The Project Manageris a fresh approach to project management: it moves beyond the formal methodologies and techniques to shed light on the core skills that will make you a great project manager. It puts the project manager centre stage and provides you with an invaluable set of experience-based lessons, tips, and advice to help you consistently deliver the results you want. Whether you are a project manager yourself, or someone who works with or recruits project managers, this book will be essential reading.

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Project management for dummies

Complete with helpful tips on delegating, shortening schedules, and optimizing your own performance Project Management for Dummies, help you get your project, and your career, off

More than two thirds of American companies use teams to execute their most important projects, making project management a highly valuable skill for advancing your career. Project Management For Dummies, Second Edition introduces you to the principles of successful project management and shows you how to motivate any team to gain maximum productivity.

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Project management how to deliver a successful project

What lies at the beating heart of this book is the structure of a strategy to ensure that every project is successful

Here is how to plan and deliver a successful project. Who else needs to manage a project? Well frankly everyone working in the public or private sector. Yet how many of us get adequately trained in how to do it? This is where this book can help. Written by an experienced practitioner, what lies at the beating heart of this book is the structure of a strategy to ensure that every project is successful. If you do what the author says, you will deliver on time and to budget.

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Project manager book of checklists

How to complete a project successfully, smoothly and on time: Everything You Need to Complete a Project Successfully, Smoothly and on Time

Managers are faced with complex tasks all the time. Completing these tasks may require setting up and running a project or on other occasions it may need a short, structured action plan.A huge amount of approaches exist, in thousands of books, to help managers complete tasks. Occasionally, a manager has the time to go off and read a text on a topic like how to manage a project, but often they have an immediate requirement to do something now. There isn’t time to plough through a project management book. Usually, all that is needed is a simple list of steps, a checklist that the manager can read to kick start them into action. The core contents of this book will follow a standard project management process – starting in initial concept identification, and going through to complete implementation. At each stage there are tasks and problems that face project managers, and for each identified task or problem there will be a checklist. Unlike normal project management texts, which are written to be read end-to-end, this book is designed to act as an everyday reference source that will be picked up and used every time the question “how do I …..” comes into the readers mind. The book will sit on a manager’s desk at work and be referenced regularly. It will become as much an important supporting tool as a book to read.

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Online game

The significance of video games within our everyday lives has certainly been increased and shaped by new technologies and gaming patterns, including the rise of home-based games consoles, advances in mobile telephone technology, the rise in more ‘sociable’ forms of gaming, and of course the advent of the Internet.

There is little question of the social, cultural and economic importance of video games in the world today, with gaming now rivalling the movie and music sectors as a major leisure industry and pastime. The significance of video games within our everyday lives has certainly been increased and shaped by new technologies and gaming patterns, including the rise of home-based games consoles, advances in mobile telephone technology, the rise in more ‘sociable’ forms of gaming, and of course the advent of the Internet. This book explores the opportunities, challenges and patterns of gameplay and sociality afforded by the Internet and online gaming. Bringing together a series of original essays from both leading and emerging academics in the field of game studies, many of which employ new empirical work and innovative theoretical approaches to gaming, this book considers key issues crucial to our understanding of online gaming and associated social relations, including: patterns of play, legal and copyright issues, player production, identity construction, gamer communities, communication, patterns of social exclusion and inclusion around religion, gender and disability, and future directions in online gaming.

An online game is a video game that is either partially or primarily played through the Internet or another computer network. Online games are ubiquitous on modern gaming platforms, including PCs, consoles and mobile devices, and span many genres, includin

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Online marketing

Online Marketing for Small Businesses in easy steps – includes social media marketing

Online presence has become vital for all businesses; large, small or the self-employed. Whether you like it or not, if you don’t take steps and manage your online presence, your customers and clients will. It’s not enough to just have a website; social networking sites are the new word of mouth marketing channels and they’re very powerful in spreading the word. To achieve this successfully adds more work to your busy day, but marketing your products and services online enables to you to reach potential customers with very little financial outlay. Lots of online marketing can be done for free and you can save costs in advertising in publications, and printing leaflets and brochures.

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Welsh way

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REWORK (book)

Change the Way You Work Forever

From the founders of the trailblazing software company 37signals, here is a different kind of business book – one that explores a new reality. Today, anyone can be in business. Tools that used to be out of reach are now easily accessible. Technology that cost thousands is now just a few pounds or even free. Stuff that was impossible just a few years ago is now simple. That means anyone can start a business. And you can do it without working miserable 80-hour weeks or depleting your life savings. You can start it on the side while your day job provides all the cash flow you need. Forget about business plans, meetings, office space – you don’t need them. With its straightforward language and easy-is-better approach, Rework is the perfect playbook for anyone who’s ever dreamed of doing it on their own. Hardcore entrepreneurs, small-business owners, people stuck in day jobs who want to get out, and artists who don’t want to starve anymore will all find valuable inspiration and guidance in these pages.

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Scrum methodology

The First Agile Methodology For Managing Product Development Step-By-Step

Scrum is a framework for developing and sustaining complex products. It is a framework within which people can address complex adaptive problems, while productively and creatively delivering products of the highest possible value. Scrum is lightweight; simple to understand and not difficult to master.

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Smashing jquery

Professional Techniques with Ajax and JQuery

From the world′s most popular resource for web designers and developer′s comes the ultimate guide to jQuery. Begins with an exploration of fundamental jQuery concepts such as Document Object Model (DOM) scripting. Explores writing “Don′t Repeat Yoursefl” (DRY) to gain a comprehensive understanding of these imperative modern techniques and best practices. Shows how jQuery enables the user to adhere to these modern best practices with ease. The succeeding chapters discuss a specific part of jQuery development such as manipulating the DOM, working with Ajax, and adding slick animation effects through tutorial style learning approach that utilizes working examples to explore the concept. The books caps off by discussing popular ways of extending the core jQuery library with pugins and building web interfaces using jQuery UI#

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The opposable mind

How Successful Leaders Win Through Integrative Thinking

If you want to be as successful as Jack Welch, Larry Bossidy, or Michael Dell, read their autobiographical advice books, right? Wrong, says Roger Martin in The Opposable Mind. Though following best practice can help in some ways, it also poses a danger: By emulating what a great leader did in a particular situation, you’ll likely be terribly disappointed with your own results. Why? Your situation is different. Instead of focusing on what exceptional leaders do, we need to understand and emulate how they think. Successful businesspeople engage in what Martin calls integrative thinking creatively resolving the tension in opposing models by forming entirely new and superior ones. Drawing on stories of leaders as diverse as AG Lafley of Procter & Gamble, Meg Whitman of eBay, Victoria Hale of the Institute for One World Health, and Nandan Nilekani of Infosys, Martin shows how integrative thinkers are relentlessly diagnosing and synthesizing by asking probing questions including: What are the causal relationships at work here? and What are the implied trade-offs. Martin also presents a model for strengthening your integrative thinking skills by drawing on different kinds of knowledge including conceptual and experiential knowledge.

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The spirt of success

The spirt of success

Who are you? Why are you living and working in the way that you are? What might you yet become and do with your life? The answer to these three fundamental questions lie at the heart of this revolutionary guide to changing the way we live and work. If we work with our heart as well as our head, we can get beyond simply functioning to realise our true potential. We will discover the things in life which make us feel whole, excited, creative and motivated. In touch with our humanity, we will become better leaders too – more inspirational, more visionary, more understanding. Introducing us to the invaluable principles and practices which can redefine our lives – as they have countless others – Norman Drummond gives meaning and purposes back to our working lives – and connect us to the true spirit of success.

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Thinking fast and slow

The phenomenal international bestseller – over 1.5 millions copies sold – that will change the way you make decisions

Why is there more chance we’ll believe something if it’s in a bold type face? Why are judges more likely to deny parole before lunch? Why do we assume a good-looking person will be more competent? The answer lies in the two ways we make choices: fast, intuitive thinking, and slow, rational thinking. This book reveals how our minds are tripped up by error and prejudice (even when we think we are being logical), and gives you practical techniques for slower, smarter thinking. It will enable to you make better decisions at work, at home, and in everything

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