If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, summoning a repair team before allowing the cell to carry on dividing
All of us have lurking in our DNA a most remarkable gene, which has a crucial job – it protects us from cancer. Known simply as p53, this gene constantly scans our cells to ensure that they grow and divide without mishap, as part of the routine maintenance of our bodies. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, summoning a repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control, p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged or prevented from functioning normally. Perhaps unsurprisingly, p53 is the most studied single gene in history. This book tells the story of medical science’s mission to unravel the mysteries of this crucial gene, and to get to the heart of what happens in our cells when they turn cancerous. Through the personal accounts of key researchers, p53: The Gene that Cracked the Cancer Code reveals the fascination of the quest for scientific understanding, as well as the huge excitement of the chase for new cures – the hype, the enthusiasm, the lost opportunities, the blind alleys, and the thrilling breakthroughs. And as the long-anticipated revolution in cancer treatment tailored to each individual patient’s symptoms begins to take off at last, p53 remains at the cutting edge.
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various or
How to Regain Control of Your Health and Your Life
If you or someone you love has been diagnosed with cancer, you want to do everything possible to beat the disease. But with so much conflicting advice and so many options available, how do you decide on the best treatment plan for you? In this major new book, Professor Jane Plant and Professor Mustafa Djamgoz present a clear and scientifically sound 10-step programme to help you beat cancer. At a time when you may be feeling helpless and confused, this book provides the essential guidance you need to take control of your life and regain your health with targeted advice for specific cancers.
The Cancer Chronicles: Unlocking Medicine’s Deepest Mystery
When the woman he loved was diagnosed with a metastatic cancer, science-writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is that a revolution is now under way – an explosion of new ideas about what cancer really is and where it comes from. He combs through the realms of epidemiology, clinical trials, laboratory experiments and scientific hypotheses, to reveal what we know and don’t know about cancer, showing why a cure remains such a slippery concept. His luminous accounts describe tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them against the body.
Workouts for shredding abs, sculpting massive biceps, pecs, delts, glutes and more!
The Men’s Health Little Book of Exercises is a handy instruction manual to more than 250 of the best exercises and workouts for torching fat and losing weight, shredding abs, and sculpting massive biceps, pecs, delts, glutes and more! With detailed step-by-step photos, the book will instruct you how to execute each move with perfect form to challenge every muscle fibre for better, faster results. Special advice includes ‘how to add 50 pounds to your bench press’, ’10 ways to add inches to your arms’, ‘the best abs exercises you’re not doing but should’ and ‘4 surprising foods that burn fat and build muscle’.
Physical exercise is any bodily activity that enhances or maintains physical fitness and overall health and wellness. It is performed for various reasons, including increasing growth and development, preventing aging, strengthening muscles and the cardiova